Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations [Brain 2021]

Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss [Angiogenesis 2024]

Single-cell sequencing reveals that endothelial cells, EndMT cells and mural cells contribute to the pathogenesis of cavernous malformations [Experimental Molecular Medicine 2023]

Cover Article — Genetic mechanisms of CCMs

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations [Brain 2021]

Angiopoietin-2 Inhibition and Pericyte Regulation in bAVMs

Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss [Angiogenesis 2024]

Single-Cell Landscape of CCMs

Single-cell sequencing reveals that endothelial cells, EndMT cells and mural cells contribute to the pathogenesis of cavernous malformations [Experimental Molecular Medicine 2023]

FEATURED PUBLICATIONS

Effect of thalidomide on sporadic central nervous system arteriovenous malformations
Yu J, Zhang H, Zhang S, Tu T, Li J, Ren J, Zhang S, Chen J, Zeng G, Jiang C, Bian L, Peng H, Krings T, Dmytriw AA, Wang Y, Kong W, Zhang H, Hong T.
Science Bulletin (2026) DOI: 10.1016/j.scib.2026.05.076.

Angiogenic switching in cerebral cavernous malformations driven by MAP3K3-PIK3CA synergy
Ren J, Ren Y, Tian A, Cui Z, Wang D, Yu H, Jiang C, Yu J, Zhang S, Chen J, Liang S, Gu Y, Wang Y, Lei J, Zheng X, Xing D, Zhang H, Hong T.
Brain (2026) DOI: 10.1093/brain/awag017.

Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Tu T, Zhang S, Li J, Jiang C, Ren J, Zhang S, Meng X, Peng H, Xing D, Zhang H, Hong T, Yu J.
Angiogenesis (2024) DOI: 10.1007/s10456-024-09957-1.

Somatic Braf^V600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Tu T, Yu J, Jiang C, Zhang S, Li J, Ren J, Zhang S, Zhou Y, Cui Z, Lu H, Meng X, Wang Z, Xing D, Zhang H, Hong T.
Angiogenesis (2024) DOI: 10.1007/s10456-024-09918-8.

Single-cell sequencing reveals that endothelial cells, EndMT cells and mural cells contribute to the pathogenesis of cavernous malformations
Ren J, Xiao X, Li R, Lv C, Zhang Y, Wang L, Hong T, Zhang H, Wang Y.
Experimental Molecular Medicine (2023) DOI: 10.1038/s12276-023-00962-w.

Cellular Origin of Sporadic CCMs
Ren J, Hong T, Zhang H.
New England Journal of Medicine (2022) DOI: 10.1056/NEJMc2117812.

Natural History and Clinical Outcomes of Paravertebral Arteriovenous Shunts
Feng Y, Yu J, Xu J, He C, Bian L, Li G, Ye M, Hu P, Sun L, Jiang N, Ling F, Hong T, Zhang H.
Stroke (2021) DOI: 10.1161/STROKEAHA.120.033963.

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y.
Brain (2021) DOI: 10.1093/brain/awab117.

Combined Cranial Intraosseous and Cerebral Cavernous Malformations With Pathogenic CCM1 Germline Sequence Variations
Ren J, Wei Y, Hong T.
JAMA Neurology (2021) DOI: 10.1001/jamaneurol.2020.4134.

Natural history of spinal cord arteriovenous shunts: an observational study
Yu JX, Hong T, Krings T, He C, Ye M, Sun LY, Zhai XD, Xiang SS, Ma YJ, Bian LS, Ren J, Tao PY, Li JW, Yang F, Li GL, Ling F, Zhang HQ.
Brain (2019) DOI: 10.1093/brain/awz153.

High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations
Hong T, Yan Y, Li J, Radovanovic I, Ma X, Shao YW, Yu J, Ma Y, Zhang P, Ling F, Huang S, Zhang H, Wang Y.
Brain (2019) DOI: 10.1093/brain/awy307.

Cover Article — Genetic mechanisms of CCMs

Angiopoietin-2 Inhibition and Pericyte Regulation in bAVMs

Single-Cell Landscape of CCMs

FEATURED PUBLICATIONS

FULL PUBLICATIONS